Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction
نویسندگان
چکیده
منابع مشابه
SPARC mediates early extracellular matrix remodeling following myocardial infarction.
Secreted protein, acidic, and rich in cysteine (SPARC) is a matricellular protein that functions in the extracellular processing of newly synthesized collagen. Collagen deposition to form a scar is a key event following a myocardial infarction (MI). Because the roles of SPARC in the early post-MI setting have not been defined, we examined age-matched wild-type (WT; n=22) and SPARC-deficient (nu...
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OBJECTIVE Evaluate the effects of VEGF165 gene transfer in the process of remodeling of the extracellular matrix after an acute myocardial infarct. METHODS Wistar rats were submitted to myocardial infarction, after the ligation of the left descending artery, and the left ventricle ejection fraction was used to classify the infarcts into large and small. The animals were divided into groups of...
متن کاملGalectin-3 and post-myocardial infarction cardiac remodeling.
This review summarizes the current literature regarding the involvement and the putative role(s) of galectin-3 in post-myocardial infarction cardiac remodeling. Post-myocardial infarction remodeling is characterized by acute loss of myocardium, which leads to structural and biomechanical changes in order to preserve cardiac function. A hallmark herein is fibrosis formation, both in the early an...
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Results Left ventricular end-systolic volume progressively increased by 190% with MR versus 90% without MR (p 0.02). Pre-load–recruitable stroke work declined by 82 13% versus 25 16% (p 0.01) with MR, with decreased remote-zone sarcoplasmic reticulum Ca -ATPase levels (0.56 0.03 vs. 0.76 0.02, p 0.001), and decreased isolated myocyte contractility. In remote zones, pro-hypertrophic Akt and gp13...
متن کاملUsing extracellular matrix proteomics to understand left ventricular remodeling.
Survival following myocardial infarction has improved substantially over the last 40 years; however, the incidence of subsequent congestive heart failure has increased dramatically as a consequence. Discovering plasma markers that signify adverse cardiac remodeling may allow high-risk patients to be recognized earlier and may provide an improved way to assess treatment efficacy. Alterations in ...
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ژورنال
عنوان ژورنال: Clinical Proteomics
سال: 2016
ISSN: 1542-6416,1559-0275
DOI: 10.1186/s12014-016-9120-2